Drug interactions
Insulin aspart protamine / insulin aspart + Losartan
Severity: Minor
Insulin aspart protamine / insulin aspart and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may enhance insulin sensitivity and increase the glucose-lowering effect of insulin. This can occasionally lead to hypoglycemia, especially early in therapy.
What this interaction means in plain words
Insulin aspart protamine / insulin aspart and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Improved insulin sensitivity from angiotensin II receptor blockade adds to insulin glucose lowering.
What to do
Monitor blood glucose more frequently when losartan is started or changed and reduce insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Insulin aspart protamine / insulin aspart with Losartan?
MediHelp rates the interaction as minor. Insulin aspart protamine / insulin aspart and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Angiotensin receptor blockers may enhance insulin sensitivity and increase the glucose-lowering effect of insulin. This can occasionally lead to hypoglycemia, especially early in therapy.
How serious is the interaction between Insulin aspart protamine / insulin aspart and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when losartan is started or changed and reduce insulin dose if hypoglycemia occurs.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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