Drug interactions
Insulin aspart protamine / insulin aspart + Testosterone
Severity: Moderate
Insulin aspart protamine / insulin aspart and Testosterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgens can improve insulin sensitivity and lower glucose, possibly increasing the effect of insulin and the risk of hypoglycemia.
What this interaction means in plain words
Insulin aspart protamine / insulin aspart and Testosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose-lowering through androgen-mediated increases in insulin sensitivity.
What to do
Monitor blood glucose after starting or changing testosterone and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Testosterone
- Testosterone + Warfarin Major
- Androstenedione + Testosterone Moderate
- Betamethasone + Testosterone Moderate
- Carbamazepine + Testosterone Moderate
- Corticotropin + Testosterone Moderate
- Cortisone + Testosterone Moderate
Frequently asked questions
Can I take Insulin aspart protamine / insulin aspart with Testosterone?
MediHelp rates the interaction as moderate. Insulin aspart protamine / insulin aspart and Testosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgens can improve insulin sensitivity and lower glucose, possibly increasing the effect of insulin and the risk of hypoglycemia.
How serious is the interaction between Insulin aspart protamine / insulin aspart and Testosterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing testosterone and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Testosterone?
MediHelp also lists interactions of Testosterone with, for example, Warfarin, Androstenedione, Betamethasone. The full list is on the Testosterone page.
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