Drug interactions
Insulin degludec + Irbesartan
Severity: Moderate
Insulin degludec and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may improve insulin sensitivity and can enhance the glucose-lowering effect of insulin. Hypoglycemia is possible, especially early in combined therapy.
What this interaction means in plain words
Insulin degludec and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Irbesartan belongs to Cardiovascular.
Why it happens
Improved insulin sensitivity from angiotensin II receptor blockade adds to the glucose-lowering action of insulin.
What to do
Monitor blood glucose more frequently when starting or changing irbesartan, and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Irbesartan?
MediHelp rates the interaction as moderate. Insulin degludec and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers may improve insulin sensitivity and can enhance the glucose-lowering effect of insulin. Hypoglycemia is possible, especially early in combined therapy.
How serious is the interaction between Insulin degludec and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or changing irbesartan, and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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