Drug interactions
Insulin degludec + Nebivolol
Severity: Moderate
Insulin degludec and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can mask adrenergic warning symptoms of hypoglycemia such as tremor and palpitations and may prolong recovery. They can also change glycemic control in either direction. Nebivolol is cardioselective, which reduces but does not remove this concern.
What this interaction means in plain words
Insulin degludec and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Nebivolol belongs to Cardiovascular.
Why it happens
Beta-blockade blunts adrenergic hypoglycemia symptoms and glycogenolysis and may alter insulin secretion.
What to do
Increase blood glucose monitoring after starting or changing nebivolol and counsel patients that sweating may be the main sign of hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Nebivolol?
MediHelp rates the interaction as moderate. Insulin degludec and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can mask adrenergic warning symptoms of hypoglycemia such as tremor and palpitations and may prolong recovery. They can also change glycemic control in either direction. Nebivolol is cardioselective, which reduces but does not remove this concern.
How serious is the interaction between Insulin degludec and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase blood glucose monitoring after starting or changing nebivolol and counsel patients that sweating may be the main sign of hypoglycemia.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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