Drug interactions
Insulin degludec + Ritonavir
Severity: Moderate
Insulin degludec and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir can induce insulin resistance and hyperglycemia, which may weaken the effect of insulin degludec. Diabetes control may worsen.
What this interaction means in plain words
Insulin degludec and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Ritonavir belongs to Anti Virals.
Why it happens
Protease inhibitors reduce peripheral insulin sensitivity and may impair insulin secretion.
What to do
Monitor blood glucose after starting or stopping ritonavir and adjust the insulin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Insulin degludec with Ritonavir?
MediHelp rates the interaction as moderate. Insulin degludec and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir can induce insulin resistance and hyperglycemia, which may weaken the effect of insulin degludec. Diabetes control may worsen.
How serious is the interaction between Insulin degludec and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping ritonavir and adjust the insulin dose.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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