Drug interactions
Insulin degludec + Thioridazine
Severity: Minor
Insulin degludec and Thioridazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines can alter glucose tolerance and may raise blood glucose, which may reduce the effect of insulin. The effect with thioridazine is generally modest and variable. Glycemic control may need adjustment when the antipsychotic is started or stopped.
What this interaction means in plain words
Insulin degludec and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec belongs to Endocrine; Thioridazine belongs to Central Nervous System.
Why it happens
Phenothiazine-related impaired glucose tolerance and reduced insulin sensitivity, mechanism not fully defined.
What to do
Monitor blood glucose more frequently when starting or stopping thioridazine and adjust the insulin degludec dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Thioridazine?
MediHelp rates the interaction as minor. Insulin degludec and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines can alter glucose tolerance and may raise blood glucose, which may reduce the effect of insulin. The effect with thioridazine is generally modest and variable. Glycemic control may need adjustment when the antipsychotic is started or stopped.
How serious is the interaction between Insulin degludec and Thioridazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or stopping thioridazine and adjust the insulin degludec dose as needed.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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