Drug interactions
Insulin degludec / insulin aspart + Lurasidone
Severity: Moderate
Insulin degludec / insulin aspart and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics can impair glycemic control. Lurasidone has a relatively low risk but may still raise glucose, which could reduce the effectiveness of insulin.
What this interaction means in plain words
Insulin degludec / insulin aspart and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition: antipsychotic-associated insulin resistance and hyperglycemia.
What to do
Monitor blood glucose more often when lurasidone is started or changed and adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Lurasidone?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antipsychotics can impair glycemic control. Lurasidone has a relatively low risk but may still raise glucose, which could reduce the effectiveness of insulin.
How serious is the interaction between Insulin degludec / insulin aspart and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when lurasidone is started or changed and adjust the insulin dose as needed.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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