Drug interactions
Insulin degludec / insulin aspart + Metoprolol
Severity: Moderate
Insulin degludec / insulin aspart and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can mask adrenergic warning signs of hypoglycemia such as tremor and tachycardia, and can prolong recovery from hypoglycemia. Glycemic control may also shift in either direction.
What this interaction means in plain words
Insulin degludec / insulin aspart and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-blockade masks adrenergic hypoglycemia symptoms and impairs glycogenolysis and glucose counter-regulation.
What to do
Monitor blood glucose more often when starting or changing metoprolol and teach the patient that sweating may be the main warning sign. A cardioselective agent such as metoprolol is preferred over non-selective beta-blockers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Metoprolol?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can mask adrenergic warning signs of hypoglycemia such as tremor and tachycardia, and can prolong recovery from hypoglycemia. Glycemic control may also shift in either direction.
How serious is the interaction between Insulin degludec / insulin aspart and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when starting or changing metoprolol and teach the patient that sweating may be the main warning sign. A cardioselective agent such as metoprolol is preferred over non-selective beta-blockers.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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