Drug interactions
Insulin degludec / insulin aspart + Perphenazine
Severity: Moderate
Insulin degludec / insulin aspart and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines can alter glucose tolerance and raise blood glucose, which may reduce the effect of insulin. Glycemic control may worsen when perphenazine is started or the dose is increased.
What this interaction means in plain words
Insulin degludec / insulin aspart and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Phenothiazine-related impairment of glucose tolerance and insulin sensitivity, a pharmacodynamic antagonism of insulin.
What to do
Monitor blood glucose more frequently when perphenazine is started, changed or stopped. Adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Perphenazine?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines can alter glucose tolerance and raise blood glucose, which may reduce the effect of insulin. Glycemic control may worsen when perphenazine is started or the dose is increased.
How serious is the interaction between Insulin degludec / insulin aspart and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when perphenazine is started, changed or stopped. Adjust the insulin dose as needed.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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