Drug interactions
Insulin degludec-liraglutide + Levothyroxine
Severity: Moderate
Insulin degludec-liraglutide and Levothyroxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone increases glucose production and turnover, so levothyroxine dose changes can worsen glycemic control in people with diabetes. Insulin requirements may rise when thyroid replacement is started or increased.
What this interaction means in plain words
Insulin degludec-liraglutide and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Levothyroxine belongs to Endocrine.
Why it happens
Thyroid hormones raise gluconeogenesis, glycogen mobilization and glucose absorption, opposing antidiabetic effect.
What to do
Monitor blood glucose more frequently after starting or changing the levothyroxine dose and adjust insulin degludec-liraglutide accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Levothyroxine
Frequently asked questions
Can I take Insulin degludec-liraglutide with Levothyroxine?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone increases glucose production and turnover, so levothyroxine dose changes can worsen glycemic control in people with diabetes. Insulin requirements may rise when thyroid replacement is started or increased.
How serious is the interaction between Insulin degludec-liraglutide and Levothyroxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after starting or changing the levothyroxine dose and adjust insulin degludec-liraglutide accordingly.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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