Drug interactions
Insulin degludec-liraglutide + Nadolol
Severity: Moderate
Insulin degludec-liraglutide and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol, a non-selective beta-blocker, can prolong insulin-induced hypoglycemia and conceal its warning signs. It may also cause hyperglycemia by reducing insulin secretion.
What this interaction means in plain words
Insulin degludec-liraglutide and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Nadolol belongs to Cardiovascular.
Why it happens
Non-selective beta-blockade impairs hepatic glycogenolysis and adrenergic symptom recognition.
What to do
Monitor blood glucose more frequently, especially after dose changes. Educate the patient about masked hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Insulin degludec-liraglutide with Nadolol?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nadolol, a non-selective beta-blocker, can prolong insulin-induced hypoglycemia and conceal its warning signs. It may also cause hyperglycemia by reducing insulin secretion.
How serious is the interaction between Insulin degludec-liraglutide and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently, especially after dose changes. Educate the patient about masked hypoglycemia symptoms.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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