Drug interactions
Insulin degludec-liraglutide + Quetiapine
Severity: Moderate
Insulin degludec-liraglutide and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is associated with weight gain, hyperglycemia and worsening glycemic control, which can counteract insulin degludec-liraglutide. Patients with diabetes may need more intensive therapy while on the antipsychotic.
What this interaction means in plain words
Insulin degludec-liraglutide and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Quetiapine belongs to Central Nervous System.
Why it happens
Atypical antipsychotics induce insulin resistance and weight gain and may impair insulin secretion, opposing antidiabetic drugs.
What to do
Monitor fasting glucose and HbA1c regularly after starting or increasing quetiapine. Increase the antidiabetic dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Insulin degludec-liraglutide with Quetiapine?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is associated with weight gain, hyperglycemia and worsening glycemic control, which can counteract insulin degludec-liraglutide. Patients with diabetes may need more intensive therapy while on the antipsychotic.
How serious is the interaction between Insulin degludec-liraglutide and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c regularly after starting or increasing quetiapine. Increase the antidiabetic dose as needed.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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