Drug interactions
Insulin degludec-liraglutide + Repaglinide
Severity: Moderate
Insulin degludec-liraglutide and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide stimulates insulin secretion independently of glucose-lowering by basal insulin and liraglutide. Using them together raises the risk of hypoglycemia, which can be serious.
What this interaction means in plain words
Insulin degludec-liraglutide and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Additive glucose lowering from insulin secretagogue action combined with exogenous insulin and GLP-1 receptor agonism.
What to do
Monitor blood glucose closely and consider reducing the repaglinide or insulin dose. Counsel the patient on recognizing and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Insulin degludec-liraglutide with Repaglinide?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repaglinide stimulates insulin secretion independently of glucose-lowering by basal insulin and liraglutide. Using them together raises the risk of hypoglycemia, which can be serious.
How serious is the interaction between Insulin degludec-liraglutide and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and consider reducing the repaglinide or insulin dose. Counsel the patient on recognizing and treating hypoglycemia.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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