Drug interactions
Insulin degludec-liraglutide + Thioridazine
Severity: Moderate
Insulin degludec-liraglutide and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine, a phenothiazine, can raise blood glucose and so reduce control in patients taking insulin degludec-liraglutide. Glycemic control may worsen after the antipsychotic is started or its dose is raised.
What this interaction means in plain words
Insulin degludec-liraglutide and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Thioridazine belongs to Central Nervous System.
Why it happens
Phenothiazines can reduce insulin sensitivity and secretion, giving a pharmacodynamic opposition to antidiabetic therapy.
What to do
Monitor blood glucose and HbA1c after starting or changing thioridazine. Adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin degludec-liraglutide and Thioridazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin degludec-liraglutide
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Insulin degludec-liraglutide with Thioridazine?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine, a phenothiazine, can raise blood glucose and so reduce control in patients taking insulin degludec-liraglutide. Glycemic control may worsen after the antipsychotic is started or its dose is raised.
How serious is the interaction between Insulin degludec-liraglutide and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing thioridazine. Adjust the antidiabetic regimen as needed.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
