Drug interactions
Insulin detemir + Liraglutide
Severity: Moderate
Insulin detemir and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide with insulin improves glycemic control but increases hypoglycemia risk, so insulin doses often need reduction.
What this interaction means in plain words
Insulin detemir and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin detemir belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Additive glucose lowering from GLP-1 receptor agonism and exogenous insulin.
What to do
Monitor glucose and consider lowering the insulin detemir dose when starting liraglutide. Do not mix the two in the same injection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Liraglutide
Frequently asked questions
Can I take Insulin detemir with Liraglutide?
MediHelp rates the interaction as moderate. Insulin detemir and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide with insulin improves glycemic control but increases hypoglycemia risk, so insulin doses often need reduction.
How serious is the interaction between Insulin detemir and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and consider lowering the insulin detemir dose when starting liraglutide. Do not mix the two in the same injection.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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