Drug interactions
Insulin glargine + Lonapegsomatropin
Severity: Moderate
Insulin glargine and Lonapegsomatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone reduces insulin sensitivity, particularly at higher doses, which can raise glucose and increase insulin requirements in patients with diabetes. Glycemic control may deteriorate if the insulin dose is not adjusted.
What this interaction means in plain words
Insulin glargine and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine belongs to Endocrine; Lonapegsomatropin belongs to Endocrine.
Why it happens
Growth hormone antagonizes insulin action by promoting lipolysis and reducing peripheral glucose uptake.
What to do
Monitor blood glucose when lonapegsomatropin is started or its dose changed, and increase the insulin glargine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Insulin glargine with Lonapegsomatropin?
MediHelp rates the interaction as moderate. Insulin glargine and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone reduces insulin sensitivity, particularly at higher doses, which can raise glucose and increase insulin requirements in patients with diabetes. Glycemic control may deteriorate if the insulin dose is not adjusted.
How serious is the interaction between Insulin glargine and Lonapegsomatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when lonapegsomatropin is started or its dose changed, and increase the insulin glargine dose as needed.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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