Drug interactions
Insulin glargine + Metoclopramide intranasal
Severity: Minor
Insulin glargine and Metoclopramide intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide speeds gastric emptying, which can change the timing of nutrient absorption relative to insulin action. This matters mainly with mealtime insulin, and the effect on basal insulin glargine is likely small.
What this interaction means in plain words
Insulin glargine and Metoclopramide intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Increased gastric motility accelerates delivery of carbohydrate to the intestine, altering the timing of postprandial glucose rise.
What to do
Monitor blood glucose after starting metoclopramide and adjust the insulin regimen if glucose control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine
Frequently asked questions
Can I take Insulin glargine with Metoclopramide intranasal?
MediHelp rates the interaction as minor. Insulin glargine and Metoclopramide intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metoclopramide speeds gastric emptying, which can change the timing of nutrient absorption relative to insulin action. This matters mainly with mealtime insulin, and the effect on basal insulin glargine is likely small.
How serious is the interaction between Insulin glargine and Metoclopramide intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting metoclopramide and adjust the insulin regimen if glucose control changes.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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