Drug interactions
Insulin glargine + Oxandrolone
Severity: Moderate
Insulin glargine and Oxandrolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxandrolone, an anabolic steroid, can increase insulin sensitivity and lower blood glucose, which may enhance the effect of insulin glargine. This raises the risk of hypoglycemia, and insulin doses may need to be reduced.
What this interaction means in plain words
Insulin glargine and Oxandrolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anabolic androgens improve insulin sensitivity and glucose handling, producing additive glucose lowering.
What to do
Monitor blood glucose closely when oxandrolone is started or stopped and reduce insulin glargine dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Frequently asked questions
Can I take Insulin glargine with Oxandrolone?
MediHelp rates the interaction as moderate. Insulin glargine and Oxandrolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxandrolone, an anabolic steroid, can increase insulin sensitivity and lower blood glucose, which may enhance the effect of insulin glargine. This raises the risk of hypoglycemia, and insulin doses may need to be reduced.
How serious is the interaction between Insulin glargine and Oxandrolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when oxandrolone is started or stopped and reduce insulin glargine dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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