Drug interactions
Insulin glargine + Sacubitril / valsartan
Severity: Moderate
Insulin glargine and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may improve insulin sensitivity, and neprilysin inhibition may also affect glucose handling. Patients on insulin may therefore have lower glucose and a higher risk of hypoglycemia.
What this interaction means in plain words
Insulin glargine and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Angiotensin receptor blockade and neprilysin inhibition may enhance insulin sensitivity; the exact mechanism is not fully established.
What to do
Monitor blood glucose when starting sacubitril/valsartan and reduce the insulin glargine dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Frequently asked questions
Can I take Insulin glargine with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Insulin glargine and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers may improve insulin sensitivity, and neprilysin inhibition may also affect glucose handling. Patients on insulin may therefore have lower glucose and a higher risk of hypoglycemia.
How serious is the interaction between Insulin glargine and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting sacubitril/valsartan and reduce the insulin glargine dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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