Drug interactions
Insulin glargine + Salsalate
Severity: Minor
Insulin glargine and Salsalate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate, a salicylate, may lower blood glucose and add to insulin's effect, raising hypoglycemia risk, especially at higher doses.
What this interaction means in plain words
Insulin glargine and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylates enhance insulin secretion and sensitivity and reduce hepatic glucose output.
What to do
Monitor glucose more often when starting or stopping salsalate and adjust the insulin dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine
Frequently asked questions
Can I take Insulin glargine with Salsalate?
MediHelp rates the interaction as minor. Insulin glargine and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salsalate, a salicylate, may lower blood glucose and add to insulin's effect, raising hypoglycemia risk, especially at higher doses.
How serious is the interaction between Insulin glargine and Salsalate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose more often when starting or stopping salsalate and adjust the insulin dose as needed.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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