Drug interactions
Insulin glargine + Sulfadiazine
Severity: Moderate
Insulin glargine and Sulfadiazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibiotics can lower blood glucose and may add to the effect of insulin, causing hypoglycemia in some patients. The risk is greater with renal impairment or poor oral intake.
What this interaction means in plain words
Insulin glargine and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfonamides may stimulate insulin secretion and displace or potentiate hypoglycemic activity, adding to insulin's glucose-lowering effect; the mechanism is not fully established.
What to do
Monitor blood glucose more frequently when starting or stopping sulfadiazine. Reduce the insulin glargine dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Frequently asked questions
Can I take Insulin glargine with Sulfadiazine?
MediHelp rates the interaction as moderate. Insulin glargine and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonamide antibiotics can lower blood glucose and may add to the effect of insulin, causing hypoglycemia in some patients. The risk is greater with renal impairment or poor oral intake.
How serious is the interaction between Insulin glargine and Sulfadiazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or stopping sulfadiazine. Reduce the insulin glargine dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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