Drug interactions
Insulin glargine + Sulfisoxazole
Severity: Moderate
Insulin glargine and Sulfisoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfisoxazole may potentiate the glucose-lowering action of insulin and cause hypoglycemia. Patients with renal impairment or irregular eating are at higher risk.
What this interaction means in plain words
Insulin glargine and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfonamides may enhance insulin secretion and hypoglycemic effect; the mechanism is not fully established.
What to do
Monitor blood glucose more closely when sulfisoxazole is started or stopped. Reduce the insulin dose if low glucose readings occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Frequently asked questions
Can I take Insulin glargine with Sulfisoxazole?
MediHelp rates the interaction as moderate. Insulin glargine and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfisoxazole may potentiate the glucose-lowering action of insulin and cause hypoglycemia. Patients with renal impairment or irregular eating are at higher risk.
How serious is the interaction between Insulin glargine and Sulfisoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more closely when sulfisoxazole is started or stopped. Reduce the insulin dose if low glucose readings occur.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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