Drug interactions
Insulin glargine-lixisenatide + Mesalamine
Severity: Minor
Insulin glargine-lixisenatide and Mesalamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mesalamine is a salicylate derivative with minimal systemic absorption at usual doses, so a clinically relevant effect on blood glucose is unlikely. A theoretical additive hypoglycemic effect applies mainly to high-dose systemic salicylates.
What this interaction means in plain words
Insulin glargine-lixisenatide and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin glargine-lixisenatide belongs to Endocrine; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
A theoretical additive glucose-lowering effect of salicylate, but systemic exposure to mesalamine is low.
What to do
No dose change is usually needed; monitor blood glucose routinely and during significant changes in mesalamine dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Mesalamine
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Mesalamine?
MediHelp rates the interaction as minor. Insulin glargine-lixisenatide and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mesalamine is a salicylate derivative with minimal systemic absorption at usual doses, so a clinically relevant effect on blood glucose is unlikely. A theoretical additive hypoglycemic effect applies mainly to high-dose systemic salicylates.
How serious is the interaction between Insulin glargine-lixisenatide and Mesalamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor blood glucose routinely and during significant changes in mesalamine dose.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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