Drug interactions
Insulin glargine-lixisenatide + Nadolol
Severity: Moderate
Insulin glargine-lixisenatide and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nonselective beta blockers can mask adrenergic warning signs of hypoglycemia such as tremor and palpitations and delay recovery from insulin-induced hypoglycemia. They may also impair insulin secretion and worsen glucose tolerance.
What this interaction means in plain words
Insulin glargine-lixisenatide and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Nadolol belongs to Cardiovascular.
Why it happens
Beta-adrenergic blockade blunts counter-regulatory glycogenolysis and hypoglycemia symptoms.
What to do
Counsel the patient that sweating may be the main warning sign and monitor blood glucose more often. Consider a cardioselective beta blocker if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Nadolol
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Nadolol?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nonselective beta blockers can mask adrenergic warning signs of hypoglycemia such as tremor and palpitations and delay recovery from insulin-induced hypoglycemia. They may also impair insulin secretion and worsen glucose tolerance.
How serious is the interaction between Insulin glargine-lixisenatide and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient that sweating may be the main warning sign and monitor blood glucose more often. Consider a cardioselective beta blocker if one is needed.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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