Drug interactions
Insulin glargine-lixisenatide + Prednisone
Severity: Moderate
Insulin glargine-lixisenatide and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic prednisone raises blood glucose and can substantially reduce the effectiveness of insulin and GLP-1 therapy. Higher doses and longer courses carry greater risk of significant hyperglycemia.
What this interaction means in plain words
Insulin glargine-lixisenatide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Prednisone belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and peripheral insulin resistance, opposing glucose lowering.
What to do
Monitor blood glucose closely during prednisone therapy and increase the insulin dose as needed. Reduce it again as the steroid is tapered to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Prednisone?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic prednisone raises blood glucose and can substantially reduce the effectiveness of insulin and GLP-1 therapy. Higher doses and longer courses carry greater risk of significant hyperglycemia.
How serious is the interaction between Insulin glargine-lixisenatide and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during prednisone therapy and increase the insulin dose as needed. Reduce it again as the steroid is tapered to avoid hypoglycemia.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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