Drug interactions
Insulin glargine-lixisenatide + Procarbazine
Severity: Minor
Insulin glargine-lixisenatide and Procarbazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak MAO-inhibiting activity, and MAOIs may potentiate the hypoglycemic effect of insulin. Evidence for this specific pair is limited and is largely extrapolated from other MAOIs.
What this interaction means in plain words
Insulin glargine-lixisenatide and Procarbazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin glargine-lixisenatide belongs to Endocrine; Procarbazine belongs to Oncology.
Why it happens
Possible MAO inhibition-related enhancement of insulin effect; the mechanism is not established.
What to do
Monitor blood glucose during procarbazine treatment and adjust the insulin dose if hypoglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Procarbazine?
MediHelp rates the interaction as minor. Insulin glargine-lixisenatide and Procarbazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Procarbazine has weak MAO-inhibiting activity, and MAOIs may potentiate the hypoglycemic effect of insulin. Evidence for this specific pair is limited and is largely extrapolated from other MAOIs.
How serious is the interaction between Insulin glargine-lixisenatide and Procarbazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during procarbazine treatment and adjust the insulin dose if hypoglycemia develops.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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