Drug interactions
Insulin glargine-lixisenatide + Tolazamide
Severity: Moderate
Insulin glargine-lixisenatide and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolazamide stimulates insulin secretion, so combining it with insulin and lixisenatide markedly increases the risk of hypoglycemia, which can be severe.
What this interaction means in plain words
Insulin glargine-lixisenatide and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering from sulfonylurea-induced insulin secretion, insulin and GLP-1 receptor agonism.
What to do
Consider reducing the sulfonylurea dose when starting the combination and monitor blood glucose closely. Educate the patient on hypoglycemia recognition and treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Tolazamide?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolazamide stimulates insulin secretion, so combining it with insulin and lixisenatide markedly increases the risk of hypoglycemia, which can be severe.
How serious is the interaction between Insulin glargine-lixisenatide and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the sulfonylurea dose when starting the combination and monitor blood glucose closely. Educate the patient on hypoglycemia recognition and treatment.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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