Drug interactions
Insulin glargine-lixisenatide + Tranylcypromine
Severity: Moderate
Insulin glargine-lixisenatide and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nonselective MAO inhibitors such as tranylcypromine can potentiate insulin-induced hypoglycemia, making episodes more frequent or prolonged in insulin-treated patients.
What this interaction means in plain words
Insulin glargine-lixisenatide and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAOIs may increase insulin sensitivity or secretion and impair counter-regulation; the exact mechanism is not fully established.
What to do
Monitor blood glucose frequently when tranylcypromine is started or stopped. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Tranylcypromine?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nonselective MAO inhibitors such as tranylcypromine can potentiate insulin-induced hypoglycemia, making episodes more frequent or prolonged in insulin-treated patients.
How serious is the interaction between Insulin glargine-lixisenatide and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when tranylcypromine is started or stopped. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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