Drug interactions
Insulin glargine-lixisenatide + Ziprasidone
Severity: Minor
Insulin glargine-lixisenatide and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone has less metabolic liability than other atypical antipsychotics but has still been linked to hyperglycemia in some patients. It may occasionally reduce the effectiveness of insulin glargine and lixisenatide.
What this interaction means in plain words
Insulin glargine-lixisenatide and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin glargine-lixisenatide belongs to Endocrine; Ziprasidone belongs to Central Nervous System.
Why it happens
Possible pharmacodynamic antagonism through antipsychotic-related effects on glucose metabolism.
What to do
Monitor blood glucose after starting ziprasidone and adjust the insulin dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Ziprasidone?
MediHelp rates the interaction as minor. Insulin glargine-lixisenatide and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ziprasidone has less metabolic liability than other atypical antipsychotics but has still been linked to hyperglycemia in some patients. It may occasionally reduce the effectiveness of insulin glargine and lixisenatide.
How serious is the interaction between Insulin glargine-lixisenatide and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting ziprasidone and adjust the insulin dose if control worsens.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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