Drug interactions
Insulin glulisine + Procarbazine
Severity: Moderate
Insulin glulisine and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has been associated with enhanced glucose-lowering and hypoglycemia in patients on insulin, though data are limited. The mechanism is not well established.
What this interaction means in plain words
Insulin glulisine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glulisine belongs to Endocrine; Procarbazine belongs to Oncology.
Why it happens
Mechanism not established; procarbazine's weak monoamine oxidase inhibiting activity may contribute to enhanced hypoglycemia.
What to do
Monitor blood glucose more frequently when procarbazine is started and adjust the insulin dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Insulin glulisine with Procarbazine?
MediHelp rates the interaction as moderate. Insulin glulisine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has been associated with enhanced glucose-lowering and hypoglycemia in patients on insulin, though data are limited. The mechanism is not well established.
How serious is the interaction between Insulin glulisine and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when procarbazine is started and adjust the insulin dose as required.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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