Drug interactions
Insulin inhaled + Metoprolol
Severity: Moderate
Insulin inhaled and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can mask adrenergic warning signs of hypoglycemia and delay recovery from it. Glycemic control may also change unpredictably in either direction.
What this interaction means in plain words
Insulin inhaled and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-blockade masks adrenergic hypoglycemia symptoms and impairs glycogenolysis and glucose counter-regulation.
What to do
Monitor blood glucose more frequently after starting or changing metoprolol and adjust the insulin dose as needed. Counsel the patient that sweating may be the main warning sign.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Insulin inhaled with Metoprolol?
MediHelp rates the interaction as moderate. Insulin inhaled and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can mask adrenergic warning signs of hypoglycemia and delay recovery from it. Glycemic control may also change unpredictably in either direction.
How serious is the interaction between Insulin inhaled and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after starting or changing metoprolol and adjust the insulin dose as needed. Counsel the patient that sweating may be the main warning sign.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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