Drug interactions
Insulin inhaled + Perphenazine
Severity: Moderate
Insulin inhaled and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine may raise blood glucose and so reduce the glucose-lowering effect of inhaled insulin. Control may deteriorate after starting or increasing the antipsychotic.
What this interaction means in plain words
Insulin inhaled and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Phenothiazine-related impairment of glucose tolerance, antagonizing insulin action.
What to do
Monitor blood glucose closely when perphenazine is started or its dose changed. Titrate insulin accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Insulin inhaled with Perphenazine?
MediHelp rates the interaction as moderate. Insulin inhaled and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine may raise blood glucose and so reduce the glucose-lowering effect of inhaled insulin. Control may deteriorate after starting or increasing the antipsychotic.
How serious is the interaction between Insulin inhaled and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when perphenazine is started or its dose changed. Titrate insulin accordingly.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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