Drug interactions
Insulin isophane protamine human + Tolazamide
Severity: Moderate
Insulin isophane protamine human and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sulfonylurea with NPH insulin gives additive glucose lowering and increases hypoglycemia risk, which may be prolonged. This is particularly relevant in elderly patients or those with renal impairment.
What this interaction means in plain words
Insulin isophane protamine human and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin isophane protamine human belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Additive effect of insulin replacement and sulfonylurea-stimulated endogenous insulin secretion.
What to do
Monitor blood glucose and reduce the dose of insulin or tolazamide if hypoglycemia occurs, especially at initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Insulin isophane protamine human with Tolazamide?
MediHelp rates the interaction as moderate. Insulin isophane protamine human and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a sulfonylurea with NPH insulin gives additive glucose lowering and increases hypoglycemia risk, which may be prolonged. This is particularly relevant in elderly patients or those with renal impairment.
How serious is the interaction between Insulin isophane protamine human and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the dose of insulin or tolazamide if hypoglycemia occurs, especially at initiation.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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