Drug interactions
Insulin lispro + Liraglutide
Severity: Moderate
Insulin lispro and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide enhances glucose-dependent insulin secretion and suppresses glucagon, so adding it to insulin raises the risk of hypoglycemia. Insulin doses often need to be reduced.
What this interaction means in plain words
Insulin lispro and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin lispro belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Additive glucose-lowering pharmacodynamic effects of exogenous insulin and GLP-1 receptor agonism.
What to do
Consider lowering the insulin dose when starting liraglutide and monitor blood glucose closely. Teach the patient to recognise hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Liraglutide
Frequently asked questions
Can I take Insulin lispro with Liraglutide?
MediHelp rates the interaction as moderate. Insulin lispro and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide enhances glucose-dependent insulin secretion and suppresses glucagon, so adding it to insulin raises the risk of hypoglycemia. Insulin doses often need to be reduced.
How serious is the interaction between Insulin lispro and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin dose when starting liraglutide and monitor blood glucose closely. Teach the patient to recognise hypoglycemia.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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