Drug interactions
Insulin lispro + Rosiglitazone
Severity: Major
Insulin lispro and Rosiglitazone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rosiglitazone improves insulin sensitivity and adds to insulin's glucose lowering, increasing hypoglycemia risk. Together they increase fluid retention, with a higher risk of edema, heart failure and possibly ischemic events.
What this interaction means in plain words
Insulin lispro and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin lispro belongs to Endocrine; Rosiglitazone belongs to Endocrine.
Why it happens
Additive glucose lowering through insulin sensitization plus insulin, with PPAR-gamma-mediated fluid retention potentiated by insulin.
What to do
Monitor for weight gain, edema and signs of heart failure, and lower the insulin dose if hypoglycemia occurs. Avoid in patients with symptomatic heart failure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin lispro
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Insulin lispro with Rosiglitazone?
MediHelp rates the interaction as major. Insulin lispro and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rosiglitazone improves insulin sensitivity and adds to insulin's glucose lowering, increasing hypoglycemia risk. Together they increase fluid retention, with a higher risk of edema, heart failure and possibly ischemic events.
How serious is the interaction between Insulin lispro and Rosiglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for weight gain, edema and signs of heart failure, and lower the insulin dose if hypoglycemia occurs. Avoid in patients with symptomatic heart failure.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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