Drug interactions
Insulin lispro + Tipranavir
Severity: Moderate
Insulin lispro and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors such as tipranavir can cause insulin resistance and hyperglycemia, which may reduce the effect of insulin lispro. Insulin requirements may rise, and new or worsened diabetes has been reported.
What this interaction means in plain words
Insulin lispro and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin lispro belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Protease inhibitors impair peripheral glucose uptake and insulin sensitivity, opposing insulin action.
What to do
Monitor blood glucose and HbA1c after starting tipranavir and increase the insulin dose as needed. Reassess the dose if the antiretroviral regimen changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Insulin lispro with Tipranavir?
MediHelp rates the interaction as moderate. Insulin lispro and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors such as tipranavir can cause insulin resistance and hyperglycemia, which may reduce the effect of insulin lispro. Insulin requirements may rise, and new or worsened diabetes has been reported.
How serious is the interaction between Insulin lispro and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting tipranavir and increase the insulin dose as needed. Reassess the dose if the antiretroviral regimen changes.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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