Drug interactions
Insulin neutral human-insulin isophane protamine human + Liraglutide
Severity: Moderate
Insulin neutral human-insulin isophane protamine human and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide with insulin increases the risk of hypoglycemia. Insulin doses often need reducing when liraglutide is started.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human-insulin isophane protamine human belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Additive glucose lowering through GLP-1 receptor-mediated glucose-dependent insulin secretion and glucagon suppression plus exogenous insulin.
What to do
Monitor glucose frequently and consider reducing the insulin dose when starting or increasing liraglutide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin neutral human-insulin isophane protamine human and Liraglutide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Liraglutide
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Liraglutide?
MediHelp rates the interaction as moderate. Insulin neutral human-insulin isophane protamine human and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide with insulin increases the risk of hypoglycemia. Insulin doses often need reducing when liraglutide is started.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose frequently and consider reducing the insulin dose when starting or increasing liraglutide.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
