Drug interactions
Insulin neutral human-insulin isophane protamine human + Losartan
Severity: Minor
Insulin neutral human-insulin isophane protamine human and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may slightly enhance insulin sensitivity, occasionally leading to hypoglycemia in insulin-treated patients. The effect is usually small.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin neutral human-insulin isophane protamine human belongs to Endocrine; Losartan belongs to Cardiovascular.
Why it happens
Possible improvement in insulin sensitivity from angiotensin receptor blockade; mechanism not firmly established.
What to do
Monitor glucose when losartan is started or changed and adjust insulin if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin neutral human-insulin isophane protamine human and Losartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Losartan?
MediHelp rates the interaction as minor. Insulin neutral human-insulin isophane protamine human and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Angiotensin receptor blockers may slightly enhance insulin sensitivity, occasionally leading to hypoglycemia in insulin-treated patients. The effect is usually small.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when losartan is started or changed and adjust insulin if hypoglycemia occurs.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
