Drug interactions
Insulin neutral human-insulin isophane protamine human + Saxagliptin
Severity: Moderate
Insulin neutral human-insulin isophane protamine human and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saxagliptin added to insulin improves glycemic control but increases the likelihood of hypoglycemia. Insulin doses may need to be lowered when starting it.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human-insulin isophane protamine human belongs to Endocrine; Saxagliptin belongs to Endocrine.
Why it happens
DPP-4 inhibition raises incretin levels, adding glucose-dependent insulin secretion and glucagon suppression to exogenous insulin effect.
What to do
Monitor blood glucose when starting saxagliptin and consider reducing the insulin dose. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Saxagliptin?
MediHelp rates the interaction as moderate. Insulin neutral human-insulin isophane protamine human and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saxagliptin added to insulin improves glycemic control but increases the likelihood of hypoglycemia. Insulin doses may need to be lowered when starting it.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting saxagliptin and consider reducing the insulin dose. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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