Drug interactions
Insulin regular human + Lurasidone
Severity: Moderate
Insulin regular human and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone, like other atypical antipsychotics, can disturb glucose metabolism and may raise blood glucose in some patients. This can reduce the effectiveness of insulin and change the insulin dose needed for glycemic control.
What this interaction means in plain words
Insulin regular human and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: antipsychotic-related metabolic effects and insulin resistance oppose the glucose-lowering action of insulin.
What to do
Monitor blood glucose and HbA1c more frequently when lurasidone is started or changed, and adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Insulin regular human with Lurasidone?
MediHelp rates the interaction as moderate. Insulin regular human and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone, like other atypical antipsychotics, can disturb glucose metabolism and may raise blood glucose in some patients. This can reduce the effectiveness of insulin and change the insulin dose needed for glycemic control.
How serious is the interaction between Insulin regular human and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c more frequently when lurasidone is started or changed, and adjust the insulin dose as needed.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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