Drug interactions
Iobenguane i + Labetalol
Severity: Major
Iobenguane i and Labetalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol blocks uptake of norepinephrine analogues into adrenergic neurons and tumour cells, which reduces iobenguane uptake. This can produce false-negative scintigraphy or reduced therapeutic effect. Iobenguane labeling advises stopping such drugs before use.
What this interaction means in plain words
Iobenguane i and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Labetalol inhibits the norepinephrine transporter, reducing cellular uptake of iobenguane.
What to do
Discontinue labetalol for several half-lives before iobenguane imaging or therapy when clinically safe, using an alternative antihypertensive meanwhile. Coordinate with the nuclear medicine team about timing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Iobenguane i with Labetalol?
MediHelp rates the interaction as major. Iobenguane i and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Labetalol blocks uptake of norepinephrine analogues into adrenergic neurons and tumour cells, which reduces iobenguane uptake. This can produce false-negative scintigraphy or reduced therapeutic effect. Iobenguane labeling advises stopping such drugs before use.
How serious is the interaction between Iobenguane i and Labetalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discontinue labetalol for several half-lives before iobenguane imaging or therapy when clinically safe, using an alternative antihypertensive meanwhile. Coordinate with the nuclear medicine team about timing.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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