Drug interactions
Iodinated glycerol + Propylthiouracil
Severity: Moderate
Iodinated glycerol and Propylthiouracil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated glycerol is an iodine-containing expectorant that delivers iodide systemically. Iodide can alter thyroid function and may add to or interfere with antithyroid therapy, with possible goiter or hypothyroidism.
What this interaction means in plain words
Iodinated glycerol and Propylthiouracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Iodide load affects thyroid hormone synthesis and release, producing additive thyroid suppression.
What to do
Avoid iodine-containing expectorants where possible, and monitor TSH and free T4 if they are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Iodinated glycerol and Propylthiouracil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Propylthiouracil
Frequently asked questions
Can I take Iodinated glycerol with Propylthiouracil?
MediHelp rates the interaction as moderate. Iodinated glycerol and Propylthiouracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iodinated glycerol is an iodine-containing expectorant that delivers iodide systemically. Iodide can alter thyroid function and may add to or interfere with antithyroid therapy, with possible goiter or hypothyroidism.
How serious is the interaction between Iodinated glycerol and Propylthiouracil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid iodine-containing expectorants where possible, and monitor TSH and free T4 if they are used.
What other medicines interact with Propylthiouracil?
MediHelp also lists interactions of Propylthiouracil with, for example, Carbamazepine, Clozapine, Methimazole. The full list is on the Propylthiouracil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
