Drug interactions
Pretomanid + Propylthiouracil
Severity: Major
Pretomanid and Propylthiouracil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid-containing regimens are associated with hepatotoxicity, and propylthiouracil can also cause severe liver injury. Used together the risk of hepatic injury is increased.
What this interaction means in plain words
Pretomanid and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pretomanid belongs to Anti Bacterial; Propylthiouracil belongs to Endocrine.
Why it happens
Additive hepatotoxicity.
What to do
Avoid propylthiouracil in favor of an alternative antithyroid drug such as methimazole; if unavoidable, monitor liver function regularly and stop for significant elevations.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propylthiouracil
Other interactions of Pretomanid
Frequently asked questions
Can I take Pretomanid with Propylthiouracil?
MediHelp rates the interaction as major. Pretomanid and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pretomanid-containing regimens are associated with hepatotoxicity, and propylthiouracil can also cause severe liver injury. Used together the risk of hepatic injury is increased.
How serious is the interaction between Pretomanid and Propylthiouracil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid propylthiouracil in favor of an alternative antithyroid drug such as methimazole; if unavoidable, monitor liver function regularly and stop for significant elevations.
What other medicines interact with Propylthiouracil?
MediHelp also lists interactions of Propylthiouracil with, for example, Carbamazepine, Clozapine, Methimazole. The full list is on the Propylthiouracil page.
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