Drug interactions
Pexidartinib + Propylthiouracil
Severity: Major
Pexidartinib and Propylthiouracil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause serious liver injury, and propylthiouracil carries a boxed warning for severe hepatotoxicity. Combining them may increase the risk of hepatic injury and complicate its attribution.
What this interaction means in plain words
Pexidartinib and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pexidartinib belongs to Oncology; Propylthiouracil belongs to Endocrine.
Why it happens
Additive hepatotoxicity from two hepatotoxic drugs.
What to do
Avoid the combination where possible, using methimazole for hyperthyroidism instead; if unavoidable, monitor liver enzymes and bilirubin frequently and stop at signs of liver injury.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propylthiouracil
Other interactions of Pexidartinib
Frequently asked questions
Can I take Pexidartinib with Propylthiouracil?
MediHelp rates the interaction as major. Pexidartinib and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause serious liver injury, and propylthiouracil carries a boxed warning for severe hepatotoxicity. Combining them may increase the risk of hepatic injury and complicate its attribution.
How serious is the interaction between Pexidartinib and Propylthiouracil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, using methimazole for hyperthyroidism instead; if unavoidable, monitor liver enzymes and bilirubin frequently and stop at signs of liver injury.
What other medicines interact with Propylthiouracil?
MediHelp also lists interactions of Propylthiouracil with, for example, Carbamazepine, Clozapine, Methimazole. The full list is on the Propylthiouracil page.
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