Drug interactions
Iodixanol + Labetalol
Severity: Moderate
Iodixanol and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Patients on beta-blockers may have more severe reactions to iodinated contrast media, and anaphylactoid reactions may respond poorly to standard epinephrine treatment. Labetalol's beta blockade blunts the reflex tachycardia and bronchodilator response.
What this interaction means in plain words
Iodixanol and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta blockade reduces responsiveness to epinephrine and compensatory cardiovascular responses during hypersensitivity reactions.
What to do
Do not stop labetalol routinely, but ensure resuscitation equipment is available and the patient is observed after contrast. Glucagon may be considered if reactions are refractory to epinephrine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Iodixanol with Labetalol?
MediHelp rates the interaction as moderate. Iodixanol and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Patients on beta-blockers may have more severe reactions to iodinated contrast media, and anaphylactoid reactions may respond poorly to standard epinephrine treatment. Labetalol's beta blockade blunts the reflex tachycardia and bronchodilator response.
How serious is the interaction between Iodixanol and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not stop labetalol routinely, but ensure resuscitation equipment is available and the patient is observed after contrast. Glucagon may be considered if reactions are refractory to epinephrine.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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