Drug interactions
Ioversol + Oxaliplatin
Severity: Minor
Ioversol and Oxaliplatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast media can cause acute kidney injury, and oxaliplatin is renally eliminated with its platinum species accumulating when kidney function falls. Reduced clearance could increase oxaliplatin toxicity, including neurotoxicity and myelosuppression. The nephrotoxic risk is modest with oxaliplatin itself.
What this interaction means in plain words
Ioversol and Oxaliplatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Contrast-induced renal impairment may reduce renal elimination of platinum species.
What to do
Ensure adequate hydration and check serum creatinine before and after contrast in patients on oxaliplatin. Monitor for increased oxaliplatin toxicity if renal function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Ioversol with Oxaliplatin?
MediHelp rates the interaction as minor. Ioversol and Oxaliplatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iodinated contrast media can cause acute kidney injury, and oxaliplatin is renally eliminated with its platinum species accumulating when kidney function falls. Reduced clearance could increase oxaliplatin toxicity, including neurotoxicity and myelosuppression. The nephrotoxic risk is modest with oxaliplatin itself.
How serious is the interaction between Ioversol and Oxaliplatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and check serum creatinine before and after contrast in patients on oxaliplatin. Monitor for increased oxaliplatin toxicity if renal function declines.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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