Drug interactions
Ioversol + Tacrolimus
Severity: Moderate
Ioversol and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast can cause acute kidney injury, and tacrolimus also causes dose-related renal vasoconstriction and nephrotoxicity. Together they raise the risk of contrast-associated renal impairment, especially in patients with existing kidney disease or volume depletion.
What this interaction means in plain words
Ioversol and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from contrast-induced tubular injury and tacrolimus-induced afferent arteriolar vasoconstriction.
What to do
Use the lowest necessary contrast volume, ensure adequate hydration, and monitor serum creatinine and tacrolimus trough levels for several days afterwards. Consider whether the study is essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ioversol and Tacrolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Ioversol with Tacrolimus?
MediHelp rates the interaction as moderate. Ioversol and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iodinated contrast can cause acute kidney injury, and tacrolimus also causes dose-related renal vasoconstriction and nephrotoxicity. Together they raise the risk of contrast-associated renal impairment, especially in patients with existing kidney disease or volume depletion.
How serious is the interaction between Ioversol and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest necessary contrast volume, ensure adequate hydration, and monitor serum creatinine and tacrolimus trough levels for several days afterwards. Consider whether the study is essential.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
