Drug interactions
Ipilimumab + Palifermin
Severity: Minor
Ipilimumab and Palifermin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin is a keratinocyte growth factor used to reduce mucositis after cytotoxic chemotherapy, and its labeling advises separating it from cytotoxic chemotherapy because it can worsen mucositis when given close to it. Ipilimumab is an immunotherapy rather than cytotoxic chemotherapy and does not cause mucositis by the same mechanism, so the concern does not clearly apply.
What this interaction means in plain words
Ipilimumab and Palifermin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ipilimumab belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
No established mechanism; the timing caution relates to proliferating epithelial cells exposed to cytotoxic agents, which ipilimumab is not.
What to do
No specific action needed beyond awareness. If given alongside cytotoxic chemotherapy, follow the palifermin timing recommendations relative to that chemotherapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ipilimumab
Other interactions of Palifermin
Frequently asked questions
Can I take Ipilimumab with Palifermin?
MediHelp rates the interaction as minor. Ipilimumab and Palifermin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Palifermin is a keratinocyte growth factor used to reduce mucositis after cytotoxic chemotherapy, and its labeling advises separating it from cytotoxic chemotherapy because it can worsen mucositis when given close to it. Ipilimumab is an immunotherapy rather than cytotoxic chemotherapy and does not cause mucositis by the same mechanism, so the concern does not clearly apply.
How serious is the interaction between Ipilimumab and Palifermin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action needed beyond awareness. If given alongside cytotoxic chemotherapy, follow the palifermin timing recommendations relative to that chemotherapy.
What other medicines interact with Ipilimumab?
MediHelp also lists interactions of Ipilimumab with, for example, Etrasimod, Vemurafenib, Ciltacabtagene autoleucel. The full list is on the Ipilimumab page.
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