Drug interactions
Ipratropium + Lofepramine
Severity: Minor
Ipratropium and Lofepramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with weaker anticholinergic effects than many tricyclics, but it can still add to the antimuscarinic effects of ipratropium. Dry mouth, constipation and urinary retention are the most likely effects, and the impact of inhaled ipratropium is small.
What this interaction means in plain words
Ipratropium and Lofepramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic symptoms, particularly in older patients or those with glaucoma or prostatic enlargement. No dose adjustment is normally required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Frequently asked questions
Can I take Ipratropium with Lofepramine?
MediHelp rates the interaction as minor. Ipratropium and Lofepramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lofepramine is a tricyclic antidepressant with weaker anticholinergic effects than many tricyclics, but it can still add to the antimuscarinic effects of ipratropium. Dry mouth, constipation and urinary retention are the most likely effects, and the impact of inhaled ipratropium is small.
How serious is the interaction between Ipratropium and Lofepramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms, particularly in older patients or those with glaucoma or prostatic enlargement. No dose adjustment is normally required.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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