Drug interactions
Ipratropium + Olanzapine / samidorphan
Severity: Moderate
Ipratropium and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has antimuscarinic activity, and together with ipratropium it may add to anticholinergic effects such as constipation, urinary retention and dry mouth. Olanzapine labeling warns of severe gastrointestinal hypomotility with other anticholinergic drugs.
What this interaction means in plain words
Ipratropium and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor bowel function and urinary symptoms, and treat constipation early. Consider a laxative if bowel habits change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Frequently asked questions
Can I take Ipratropium with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Ipratropium and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has antimuscarinic activity, and together with ipratropium it may add to anticholinergic effects such as constipation, urinary retention and dry mouth. Olanzapine labeling warns of severe gastrointestinal hypomotility with other anticholinergic drugs.
How serious is the interaction between Ipratropium and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and urinary symptoms, and treat constipation early. Consider a laxative if bowel habits change.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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